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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
20.3
Human Site:
S314
Identified Species:
29.78
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S314
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S314
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
D383
R
T
Y
D
E
K
V
D
L
W
C
I
G
V
L
Dog
Lupus familis
XP_853397
405
45606
S315
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
S305
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
Rat
Rattus norvegicus
P59241
397
44856
S307
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
G215
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
Chicken
Gallus gallus
XP_425725
409
46456
M314
L
D
Y
L
P
P
E
M
I
E
G
R
T
H
D
Frog
Xenopus laevis
Q91819
408
46443
W320
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
L232
S
H
D
E
K
V
D
L
W
S
I
G
V
L
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
L240
D
Q
W
C
L
G
I
L
C
Y
E
F
V
V
G
Honey Bee
Apis mellifera
XP_395732
327
37711
H239
E
M
I
N
G
N
T
H
D
H
T
V
D
L
W
Nematode Worm
Caenorhab. elegans
O01427
305
34731
Y217
W
A
I
G
V
L
C
Y
E
F
L
V
G
K
P
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
L190
D
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
S194
E
S
V
E
H
D
A
S
V
D
I
W
S
L
G
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
D279
M
V
E
S
R
E
Y
D
H
T
I
D
A
W
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
0
0
0
0
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
20
100
N.A.
100
100
N.A.
20
33.3
20
13.3
N.A.
13.3
13.3
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
7
0
0
0
0
0
7
0
7
% A
% Cys:
0
0
0
7
0
0
7
0
7
0
13
7
32
7
7
% C
% Asp:
44
13
13
13
32
13
7
13
7
7
0
7
7
0
7
% D
% Glu:
13
32
13
13
7
7
7
0
7
7
7
0
7
7
32
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
7
0
7
7
% F
% Gly:
0
0
0
7
7
7
0
7
7
32
13
7
13
0
13
% G
% His:
7
7
0
0
7
0
0
7
7
7
0
0
0
7
0
% H
% Ile:
0
0
13
0
0
0
7
0
7
0
19
7
0
0
0
% I
% Lys:
7
7
32
7
7
7
0
0
0
0
0
0
0
7
0
% K
% Leu:
7
0
0
13
13
38
13
19
38
13
13
32
7
19
13
% L
% Met:
7
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
7
7
0
7
0
7
7
38
7
7
0
0
7
0
0
% S
% Thr:
0
7
0
0
0
0
7
0
0
7
7
0
7
0
0
% T
% Val:
0
13
13
32
13
7
7
0
13
7
32
19
13
13
0
% V
% Trp:
7
0
7
0
7
7
32
7
7
7
0
7
0
7
7
% W
% Tyr:
0
0
13
0
0
0
7
7
0
7
0
7
7
32
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _